Joaloka motho ea chesehelang ho ntlafatsa bophelo bo botle le bophelo bo bolelele, potso e le 'ngoe e atisang ho hlaha ke polokeho ea ho kopanya NMN (Nicotinamide Mononucleotide) le lisebelisoa tse ling kapa meriana. Tataisong ena e felletseng, ke kenella sehloohong sena ka ho hlahloba mehloli e tšepahalang le lingoliloeng tsa mahlale ho fana ka leseli mabapi le likamano tse ka bang teng le ts'ireletso e amanang le ts'ebeliso ea NMN hammoho le litlatsetso le meriana e fapaneng.
Ho utloisisa NMN le Mokhoa oa Eona oa Ts'ebetso
Ho bohlokoa ho utloisisa mekhoa ea mantlha ea NMN ka har'a 'mele pele u kenella ka har'a litšebelisano tsa NMN le lintho tse ling. NMN ke selelekela sa coenzyme nicotinamide adenine dinucleotide (NAD +), e amehang lits'ebetsong tse fapaneng tsa cellular joalo ka metabolism ea matla le tokiso ea DNA. Ho nka li-supplement tsa NMN ho boleloa ho ts'ehetsa bophelo bo botle ba cellular le ho fokotsa litlamorao tsa botsofali ka ho phahamisa maemo a NAD +. Bakeng sa ho tseba ho lumellana ha eona le li-supplement le litlhare tse ling, ho bohlokoa ho utloisisa mokhoa ona.
Mehopolo ea Tšireletso Ha U Kopanya NMN le Lisebelisoa tse Tloaelehileng
vithamine D
Lipatlisiso li bontša hore Β-Nicotinamide Mononucleotidenmn e ka sebelisana hantle le vithamine D, kaha lintho tsena ka bobeli li kenyellelitsoe ho ts'ehetsa bophelo bo botle le bophelo bo bolelele. Leha ho le joalo, lithuto tse ling lia hlokahala ho hlakisa litlamorao tsa synergistic ka botlalo.
Omega-3 mafura a acids
Omega-3 fatty acids e ka tlatsetsa liphello tsa NMN ho bophelo bo botle ba lisele, ho latela bopaki ba pele. Leha ho le joalo, tlhokomeliso ea khothaletsoa, kaha likarolo tse ngata tsa lintlafatso tsa omega-3 li ka holisa papali ea ho shoa, haholo ha e kopantsoe le meriana e meng e fokotsang mali.
Resveratrol
Lintho tse ka 'nang tsa e-ba khahlanong le botsofali tsa resveratrol, polyphenol e fumanoang veine e khubelu le litholoana tse ling, li ithutoa. Patlisiso e 'ngoe e khothaletsa hore resveratrol le NMN li ka sebetsa ka mokhoa o ts'oanang ho ntlafatsa ts'ebetso e fapaneng ea lisele. Leha ho le joalo, litekanyetso le ho fapana ha motho ka mong ho arabela li lokela ho nkoa.
Coenzyme Q10 (CoQ10)
Coenzyme Q10 ke cofactor ea bohlokoa ea antioxidant le mitochondrial e kenyang letsoho tlhahisong ea matla a cellular. Le hoja ho na le bopaki bo fokolang bo tobileng mabapi le litšebelisano pakeng tsa NMN le CoQ10, metsoako ka bobeli e tšehetsa mosebetsi oa mitochondrial le metabolism ea cellular. Maikutlo a khopolo-taba a fana ka maikutlo a hore li ka thusana ho khothaletsa bophelo bo botle ba cellular le tlhahiso ea matla. Ho kopanya NMN le Β-Nicotinamide Mononucleotidenmn li-supplement ka kakaretso li nkuoa li bolokehile. Leha ho le joalo, likarabo tsa batho ka bomong li ka fapana, 'me bafani ba tlhokomelo ea bophelo ba lokela ho beha bakuli leihlo ho ntlafatsa litekanyetso le ho lekola melemo efe kapa efe e ka bang teng ea synergistic.
Probiotics
Ke tloaelo e tloaelehileng ho nka li-supplement tsa probiotic, tse nang le libaktheria tse molemo, ho ntlafatsa ts'ebetso ea 'mele ea ho itšireletsa mafung le bophelo bo botle ba mala. Ho boloka mala a phetseng hantle ho ka eketsa ho monya le ho sebetsa ha NMN ka tsela e sa tobang, leha ho se na bopaki bo tobileng ba litšebelisano lipakeng tsa NMN le li-probiotics.
Likamano tse ka 'nang tsa etsahala Pakeng tsa NMN le Meriana e Tloaelehileng
Meriana ea khatello ea mali
Meriana ea khatello ea mali e bohlokoa bakeng sa ho laola khatello ea mali, 'me mefuta e meng e kang ACE inhibitors (mohlala, lisinopril, enalapril) le beta-blockers (mohlala, metoprolol, carvedilol) e ka sebelisana le NMN ka lebaka la tšusumetso ea eona ho NAD+ metabolism le litsela tsa lipontšo tsa cellular. Li-inhibitors tsa ACE li thibela enzyme e fetolang angiotensin, e bohlokoa khatellong ea mali le taolong ea ts'ebetso ea methapo. Tlatsetso ea NMN e ka ama litsela tsena, e ka fetolang taolo ea khatello ea mali. Li-beta-blockers li sebetsa ka ho thibela li-receptor tsa beta-adrenergic, ho theola lebelo la pelo le khatello ea mali. NMN e ka ama li-receptor tsena kapa ts'ebetso ea pelo ka ho feto-fetoha ha molumo oa NAD +. Bakuli ba meriana ena ba lokela ho buisana bongata ba nmn nicotinamide mononucleotide phofo le bafani ba tlhokomelo ea bophelo ho hlahloba litšebelisano le ho boloka khatello ea mali e tsitsitseng ka mekhoa e nepahetseng ea ho hlahloba le ho laola.
Meriana ea lefu la tsoekere
Meriana ea lefu la tsoekere e bapala karolo ea bohlokoa ho laola boemo ba tsoekere maling ho batho ba nang le lefu la tsoekere. NMN e bonts'itse melemo e ka bang teng molemong oa ho matlafatsa kutloisiso ea insulin le metabolism ea tsoekere e ipapisitseng le lithuto tsa preclinical. Bakeng sa bakuli ba noang meriana e kang metformin (biguanide) kapa sulfonylureas (mohlala, glipizide, glyburide), ho na le ho ameha ka ho sebelisana le NMN. Metformin haholo-holo e fokotsa tlhahiso ea tsoekere ea sebete 'me e matlafatsa kutloisiso ea lisele ho insulin. Tlatsetso ea NMN e ka eketsa litlamorao tsena kapa ea sebelisana le litsela tse amehang taolong ea tsoekere, tse amang maemo a tsoekere ea mali. Li-sulfonylureas li susumetsa tlhahiso ea insulin ho tsoa liseleng tsa beta tsa pancreatic, 'me tšebeliso e tšoanang le NMN e ka eketsa tlhahiso ea insulin, e ka bakang hypoglycemia. Ka hona, ho bohlokoa ho batho ba nahanang Β-Nicotinamide Mononucleotidenmn tlatsetso hammoho le meriana ea lefu la tsoekere ho beha leihlo maemo a tsoekere ea mali le ho batla tataiso ho tsoa ho bafani ba tlhokomelo ea bophelo ho laola litšebelisano tse ka bang teng ka nepo.
Meriana e fokotsang mali
Ka lebaka la matla a tsona a anticoagulant, meriana e fokotsang mali e kang warfarin le aspirin hangata e fanoa ho thibela liketsahalo tsa pelo. NMN e khothalelitsoe ho sebelisa litlamorao tse bonolo tsa antiplatelet, tse ka 'nang tsa sebelisana hantle le litaelo tsena. Warfarin e sitisa mokhoa oa ho koala, athe aspirin e thibela ho kopana ha platelet, e leng ntho e hlokahalang bakeng sa ho thehoa ha lesela. Ho eketsoa ha NMN ho ka matlafatsa liphello tsena le ho phahamisa monyetla oa mathata a amanang le ho tsoa mali. Batho ba fokotsang mali ba lokela ho eletsa bafani ba litšebeletso tsa bongaka pele ba qala NMN Nicotinamide Mononucleotide Powder ho lekola likhokahano tse ka bang teng le ho rala mekhoa ea ho shebella ea ho okamela likotsi tse senyang.
fihlela qeto e
Qetellong, le hoja NMN e bontša tšepiso e le ts'ebetso e ka 'nang ea e-ba khahlanong le botsofali, polokeho ea eona le ho lumellana le lisebelisoa tse ling le meriana e hloka ho hlahlojoa ka hloko. Ka ho utloisisa mekhoa ea ts'ebetso ea NMN le litšebelisano tse ka bang teng, batho ba ka etsa liqeto tse nang le tsebo mabapi le ho kenyelletsa NMN lenaneong la bona la bophelo bo botle. Leha ho le joalo, ho bohlokoa ho buisana le setsebi sa tlhokomelo ea bophelo pele u qala tlatsetso efe kapa efe e ncha kapa mofuta oa meriana, haholo-holo bakeng sa ba nang le maemo a bophelo a seng a ntse a le teng kapa ba noang meriana e fanoeng ke ngaka.
Haeba u na le lipotso kapa u thahasella lihlahisoa tsa rona, ka kopo ikopanye le rona: kiyo@xarbkj.com.
References
1.Martens CR, Denman BA, Mazzo MR, Armstrong ML, Reisdorph N, McQueen MB, et al. Tlatsetso e sa foleng ea nicotinamide riboside e mamelloa hantle ebile e phahamisa NAD+ ho batho ba baholo ba phetseng hantle ba lilemo tse mahareng le ba baholo. Nat Commun. 2018;9(1):1286.
2.Imai, S. (2009). Nicotinamide phosphoribosyltransferase (Nampt): Khokahano lipakeng tsa biology ea NAD, metabolism, le mafu. Moralo oa Hona joale oa Meriana, 15(1), 20-28.
3. Elhassan YS, Kluckova K, Fletcher RS, Schmidt MS, Garten A, Doig CL, et al. Nicotinamide riboside e eketsa metabolome ea masapo a motho ea tsofetseng ea NAD+ mme e kenya li-signature tsa transcriptomic le anti-inflammatory. Cell Rep. 2019;28(7):1717-28.e6.
4.Trammell, SA, Schmidt, MS, Weidemann, BJ, Redpath, P., Jaksch, F., Dellinger, RW, ... & Brenner, C. (2016). Nicotinamide riboside e fumaneha ka tsela e ikhethang le ka molomo ho litoeba le bathong. Tlhaho ea puisano, 7(1), 1-10.
5.Yoshino, J., Mills, KF, Yoon, MJ, & Imai, S. (2011). Nicotinamide mononucleotide, NAD+ ea bohlokoa ea bohareng, e phekola lefu la tsoekere le bakoang ke lilemo ho litoeba. Metabolism ea lisele, 14 (4), 528-536.
6.Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., ... & Auwerx, J. (2016). Phetoho ea NAD+ e ntlafatsa ts'ebetso ea mitochondrial le stem cell mme e ntlafatsa nako ea bophelo ho litoeba. Saense, 352 (6292), 1436-1443.
