Na alpha lipoic acid phofo e sebetsa hantle bakeng sa ho fokotsa ho ruruha?
Alpha lipoic acid (ALA) e hapile tlhokomelo bakeng sa matla a eona a ho thibela ho ruruha. Tlhahlobisong ena e felletseng, re hlahloba bopaki ba saense bo mabapi le katleho ea alpha lipoic acid phofo ho kokobetsa ho ruruha. Ka ho sekaseka mehloli e tsebahalang le lithuto tsa lipatlisiso, re ikemiselitse ho fana ka leseli la hore na ALA ke khetho e sebetsang ea ho laola ho ruruha.
Ho utloisisa Alpha Lipoic Acid
Alpha lipoic acid, eo hape e tsejoang e le thioctic acid, ke motsoako oa tlhaho o sebetsang joalo ka antioxidant e matla 'meleng. E bapala karolo ea bohlokoa ho metabolism ea matla 'me e ithutoe bakeng sa litlamorao tse ka bang teng tsa kalafo maemong a fapaneng a bophelo, ho kenyelletsa le ho ruruha.
Mokhoa oa Ts'ebetso
Mosebetsi oa Antioxidant:
Alpha lipoic acid phofo ke antioxidant e matla e ka fokotsang li-radicals tsa mahala, e leng liathomo tse amohelang tse ka bakang kotsi ea lisele le ho baka ho teneha. Ka ho senya li-radicals tsa mahala, ALA e etsa phapang e netefatsa lisele le lisele tse tsoang ho oxidative, e leng mokhanni oa bohlokoa oa ho ruruha.
Ho feto-fetoha ha Litsela tsa Lipontšo:
ALA e 'nile ea bonahala e kena-kenana le litsela tsa lipontšo tse kenyelletsoeng ho teneha, tse kang NF-κB (sebopeho sa atomic kappa-light-chain-enhancer ea lisele tsa B tse entsoeng) tsela. NF-κB ke palo ea phetolelo e tsamaisang polelo ea litšoaneleho tse kenyellelitsoeng ho teneha le liketso tse bolokehileng. ALA e hatella ho kenngoa ha NF-κB, ka mor'a moo e fokotsa tlhahiso ea li-cytokine tse nang le pro-inflammatory le tse ling tse tsamaeang pakeng tsa ho ruruha.
Ho feta moo, ALA e ka leka-lekanya ketso ea litsela tse ling tsa lipontšo, ho bala litsela tsa MAPK (mitogen-activated protein kinase), tse kenyellelitsoeng liketsong tsa cellular ho teneha le ho otlolla. Ka ho ama litsela tsena, ALA e ka tsamaisa polelo ea litšoaneleho tse tukang le ho leka-lekanya likarabo tse tukang.
Regulation of Resistant Function:
ALA e hlalositsoe ka botlalo ho lokisa mosebetsi o bolokehileng, ho bala motsamao oa lisele tse bolokehileng joalo ka macrophages le T lymphocyte. Lisele tsena tse manganga li phetha karolo ea bohlokoa ho qaleng le ho tsamaisa liketso tse tukang. ALA e ka fana ka thuso ho leka-lekanya ketso ea lisele tse hanyetsang ho ntšetsa pele karabelo e tsitsitseng ea ho hanyetsa le hose holim'a ho ruruha ho holimo.
Tšebelisano le Metsoako e meng ea Anti-inflammatory:
Alpha lipoic acid phofo e ka amahanngoa ka mokhoa o ts'oanang le metsoako e meng e khahlanong le ho ruruha kapa litsela, ho ntlafatsa bokhoni ba bona ho loantša ho teneha. Bakeng sa papiso, ALA e hlahlobiloe hammoho le omega-3 greasy acids, curcumin, le lisebelisoa tse ling tse tloaelehileng tse thibelang ho ruruha, tse nang le liphello tse ka bang teng tsa synergistic tse shebiloeng ho liponders tsa preclinical.
|
|
|
|
Bopaki ba Saense ho Tsoa Lithuto tsa Tleliniki
Mahlaba a Manonyeletso a Rheumatoid (RA):
Teko e laoloang ka mokhoa o sa reroang e phatlalalitsoeng bukeng ea "Irritation" ka 2016 e ile ea hlahloba litlamorao tsa tlatsetso ea ALA ho matšoao a mollo le ketso ea bokuli ho bakuli ba nang le bohloko ba manonyeletso a ramatiki. Monahano o fumane hore tlatsetso ea ALA (600 mg / letsatsi bakeng sa libeke tse 12) e fokolitse ka botlalo maemo a matšoao a tukang joalo ka C-reactive protein (CRP) le erythrocyte sedimentation rate (ESR). Hape, tlatsetso ea ALA e ne e amana le lintlafatso ho lintlha tsa ts'oaetso ha li bapisoa le kalafo ea bohata. Leha ho ka ba joalo, menahano e meholo le ea nako e telele ea hlokahala ho netefatsa litšibollo tsena le ho lekola bohlokoa ba bongaka.
Ho ruruha ho Amanang le Lefu la tsoekere:
Batho ba bangata ba nahanang ka kliniki ba hlahlobile litlamorao tsa tlatsetso ea ALA ho mpefatseng ho hoholo ho bakuli ba nang le lefu la tsoekere la mofuta oa 2, boemo bo amanang le ho mpefala ha maemo a tlase. Leha batho ba 'maloa ba nahanang ba na le litlamorao tse hlakileng tsa ALA ho matšoao a phephetsang a kang CRP le interleukin-6 (IL-6), ba bang ha ba so fumane lintlafatso tsa bohlokoa. Tlhahlobo ea meta e phatlalalitsoeng bukeng ea "Tlhokomelo ea Lefu la tsoekere" ka 2011 e fihletse qeto ea hore tlatsetso ea ALA e kanna ea ba le litlamorao tse mpe ho fokotsa matšoao a ho teneha ho bakuli ba nang le lefu la tsoekere la mofuta oa 2, empa bopaki bo ne bo thibetsoe ke ho fapana ha maikutlo le mefokolo ea mekhoa.
Neuroinflammation:
Alpha lipoic acid phofo e hlahlobiloe bakeng sa litlamorao tse ka bang teng tsa ts'ireletso ea methapo maemong a khetholloang ke neuroinflammation, joalo ka lefu la Alzheimer's le mefuta e fapaneng ea sclerosis. Liteko tsa tleliniki tse hlahlobang litlamorao tsa tlatsetso ea ALA ho matšoao a neuroinflammation le mosebetsi oa kelello li hlahile li kopane. Le hoja ba 'maloa ba nahana ka lintlafatso tse qaqileng ho matšoao a oxidative push le ho teneha, ba bang ha ba so fumane litlamorao tse hlokomelehang ho matšoao a neuroinflammatory kapa liphetho tsa bongaka. Ho botsa haholoanyane ka ho hlokahala ho hlahisa melemo e ka bang teng ea ALA maemong a neuroinflammatory.
Tlhahlobo e Bapisang le Mekhatlo e meng e khahlanong le ho ruruha
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs):
Hangata li-NSAID li sebelisetsoa ho kokobetsa bohloko le ho teneha maemong a kang bohloko ba manonyeletso le ho senyeha ha mesifa le mesifa. Li sebetsa ka ho thibela lik'hemik'hale tsa COX-1 le COX-2, ka tsela ena li fokotsa tlhahiso ea li-prostaglandins tse chesang.
Ha ho bapisoa le li-NSAID, ALA e kanna ea ba le lisebelisoa tse fapaneng tsa ts'ebetso, ha e le hantle e sebelisa litlamorao tsa eona tse khahlanong le ho ruruha ka thepa ea antioxidant le ho leka-lekana ha litsela tsa matšoao. ALA ha e na monyetla oa ho baka litlamorao tsa ka mpeng hangata tse amanang le li-NSAID, joalo ka liso le mali a tsoang ka mpeng.
Leha ho le joalo, li-NSAID ka tloaelo li fana ka phokotso e potlakileng le e matla ea ho teneha le ho hlokofatsoa ha ho bapisoa le ALA. Ho feta moo, li-NSAID li fumaneha ka lintlha tse fapaneng, ho bala matlapa a molomo, litlolo tsa lihlooho, le li-infusions, tse fanang ka ho ikamahanya le maemo likhethong tsa kalafo.
Corticosteroids:
Corticosteroids ke lithethefatsi tse matla tse thibelang ho ruruha tse thibelang karabelo e sireletsehileng le ho fokotsa ho mpefala ka ho thibela ho hlahisa li-cytokine tse tukang le bakena-lipakeng.
Ha e bapisoa le corticosteroids, Alpha lipoic acid phofo e ka ba le litlamorao tse ntle, tse nang le litlamorao tse fokolang tse kang immunosuppression, osteoporosis, le adrenal concealment. ALA hangata e mamelloa hantle, 'me ho khathatsoa ke mala e le litlamorao tse atileng haholo ho litekanyetso tse telele.
Leha ho le joalo, li-corticosteroids li lula li pata ho teneha ka potlako le ka matla ha li bapisoa le ALA, e leng se etsang hore e be le kahlolo e molemo bakeng sa maemo a matla le a matla.
Metsoako ea tlhaho e khahlanong le ho ruruha (mohlala, Curcumin, Omega-3 Greasy Acids):
Metsoako ea tlhaho e khahlanong le ho ruruha joaloka curcumin (e fumanoang ka turmeric) le omega-3 greasy acids (e fumanoang ka oli ea angle) e 'nile ea nkoa e le melemo ea bona ea ho hlokomela ho ruruha.
ALA e fana ka litšoantšiso tse 'maloa le metsoako ena ho latela thepa ea eona ea antioxidant le ho leka-lekana ha litsela tse tsosang takatso. Leha ho le joalo, motsoako o mong le o mong o ka ba le likarolo tse khahlang tsa ts'ebetso mme o shebane le maikutlo a fapaneng a karabelo e tukang.
Ha e bapisoa le curcumin le omega-3 greasy acid, Alpha lipoic acid phofo e ka fana ka lintlha tsa bohlokoa joalo ka bioavailability e phahameng le ho tiea. Tlatsetso ea ALA ha e na monyetla oa ho baka litlamorao tsa ka mpeng ha e bapisoa le curcumin.
Leha ho le joalo, ho sebetsa ha ALA ho amanang le metsoako e meng e tloaelehileng e khahlanong le ho ruruha ho ka fetoha ho itšetlehile ka boemo bo itseng le karabelo ea motho.
Tšireletseho le Litla-morao
Alpha lipoic acid hangata e mamelloa hantle ha e sebelisoa ka litekanyetso tse nepahetseng. Leha ho le joalo, batho ba bang ba ka 'na ba e-ba le matšoao a fokolang a ka mpeng a kang ho nyekeloa ke pelo kapa ho se thabise ka mpeng. Ho feta moo, ALA e ka sebelisana le meriana e itseng, kahoo ho bohlokoa ho buisana le setsebi sa tlhokomelo ea bophelo pele u qala tlatsetso.
fihlela qeto e
Ha re phethela, alpha lipoic acid phofo e bontša ts'episo e le moemeli ea sebetsang hantle bakeng sa ho fokotsa ho ruruha. Bopaki ba mahlale bo fana ka maikutlo a hore ALA e na le litlamorao tse khahlanong le ho ruruha ka mekhoa e fapaneng mme e ka fana ka melemo maemong a amanang le ho ruruha ho sa foleng. Leha ho le joalo, lipatlisiso tse ling li na le mabaka a utloahalang a ho hlakisa karolo ea eona e nepahetseng le litekanyetso tse nepahetseng litabeng tse fapaneng tsa ho ruruha. Haeba u batla ho reka sehlahisoa sena, ka kopo ikopanye le rona ho kiyo@xarbkj.com.
