Na NMN e ka khutlisa botsofali kapa ea khothaletsa bophelo bo bolelele?
Joaloka motho ea hlolloang ke khopolo e makatsang ea botsofali le ho lelekisa bophelo bo bolelele, potso ea hore na β-Nicotinamide Mononucleotidenmn e na le senotlolo sa ho khutlisa botsofali kapa ho khothaletsa bophelo bo bolelele e hapile maikutlo a ka. Patlisisong ena e batsi, ke batlisisa liphuputsong tsa morao-rao tsa mahlale le lintlha tse tsoang liwebsaeteng tse maemong a holimo ho Google ho utolla 'nete e tšehetsang melemo eo ho thoeng ke NMN.
Ho utloisisa NMN:
Pele ho NAD+: β-Nicotinamide Mononucleotidenmn ke selelekela sa nicotinamide adenine dinucleotide (NAD+), coenzyme e fumanoang liseleng tsohle tse phelang. NAD+ e bapala karolo ea bohlokoa mefuteng e fapaneng ea metabolic, ho bala tlhahiso ea matla, tokiso ea DNA, le tataiso ea polelo ea boleng. Ha lisele li ntse li tsofala, maemo a NAD + a atisa ho fokotseha, a khanna mosebetsing o sa sebetseng oa liselefouno le ho eketsa ho hloka thuso ho mafu a amanang le lilemo.
Mosebetsi oa Mitochondrial: Mitochondria, eo kamehla ho thoeng ke mohloli oa matla oa sele, e ka tšeptjoa bakeng sa ho theha matla ka foreiming ea adenosine triphosphate (ATP). NMN e 'nile ea bonahala e matlafatsa mosebetsi oa mitochondrial ka ho ntlafatsa motsamao oa lik'hemik'hale tse kenyellelitsoeng molokong oa ATP, ka mor'a moo o ntšetsa pele metabolism ea cellular.
DNA Tokiso: E 'ngoe ea matšoao a ho hola ke ho bokella kotsi ea DNA ha nako e ntse e ea. NAD+ e bapala karolo ea mantlha likarolong tsa tokiso ea DNA, 'me ka ho nchafatsa maemo a NAD+, NMN e ka fana ka thuso ea ho boloka molumo oa genomic le ho lekanya litlamorao tsa tšenyo ea DNA e amanang le botsofali.
Sirtuin Enactment: NAD + ke co-substrate bakeng sa li-sirtuin, lelapa la liprotheine tse kenyellelitsoeng ho tsamaisa mefuta e fapaneng ea lisele, ho bala khōlo, tsamaiso ea tšilo ea lijo, le karabelo e otlolohileng. Ka ho kenya li-sirtuin, NMN e ka sebelisa litšusumetso tsa bohlokoa mosebetsing oa cellular le ho ntšetsa pele bophelo bo bolelele.
Menahano ea Preclinical Ponders: Menahano e fapaneng ea preclinical e nahanang ka eona, ha e le hantle e entsoeng ka mehlala ea libopuoa tse joalo ka litoeba, e bonts'itse litlamorao tse ka bang teng tse thibelang botsofali tsa tlatsetso ea NMN. Lits'oants'o tsena li hlahile liphetoho mekhoeng e fapaneng e amanang le lilemo, ho bala mosebetsi oa mitochondrial, tšusumetso e mpe, ts'ebetso ea 'mele le katoloso ea nako ea bophelo.
Liteko tsa Tleliniki: Le hoja lipatlisiso tsa pele ho kliniki li fane ka liphihlelo tse tšepisang melemo e ka bang teng ea NMN, liteko tsa meriana ho batho li ntse li tsoela pele ho lekola bokhoni ba eona le ts'ireletso. Liteko tsena li supa ho hlahloba tlatsetso ea NMN lichabeng tse fapaneng, ho bala batho ba tiileng le ba nang le maemo a amanang le lilemo, ho etsa qeto ea litlamorao tsa eona ho bophelo bo botle le bophelo bo bolelele.
Mehopolo ea Polokeho: Athe β-Nicotinamide Mononucleotidenmn ka kakaretso e nkoa e sireletsehile ebile e mamellehe hantle, tlhahisoleseling ea nako e telele ea ts'ireletso ho batho e thibetsoe. Joalo ka tlatsetso efe kapa efe ea lijo, ho bohlokoa ho eletsana le setsebi sa bophelo bo botle nakong e fetileng ha u qala tlatsetso ea NMN, haholoholo haeba u na le maemo a mantlha a kalafo kapa u noa meriana.
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Bopaki ba Mahlale:
Mosebetsi oa Mitochondrial: Ba seng bakae ba nahanang ka bona ba bontšitse hore tlatsetso ea NMN e ka ntlafatsa mosebetsi oa mitochondrial meleng e fapaneng. Bakeng sa nyeoe, ho botsa ka litoeba tse hōlileng tsebong ho hlahile hore phekolo ea NMN e hatela pele botenya ba mitochondrial, phefumoloho, le moloko oa ATP, ho khanna ho matlafatsa tsamaiso ea tšilo ea lijo le ka ts'ebetso e kholo ea liselefouno.
Tšebeliso ea insulin le bophelo bo botle ba metabolism: + β-Nicotinamide Mononucleotidenmn e fumanoe e tsoela pele ho ba le tšusumetso e mpe le ho mamella tsoekere mefuteng ea libōpuoa tsa corpulence le ho robeha ha metabolism. Ka ho ntlafatsa ts'ebetso ea tšilo ea 'mele ea cellular le ho fokotseha ha oxidative, tlatsetso ea NMN e ka fana ka thuso e leka-lekaneng ea khanyetso le ho ntlafatsa bophelo bo botle ba metabolic, e leng lintho tse bohlokoa ho ntšetseng pele bophelo bo bolelele.
Ts'ebetso ea 'Mele le Mosebetsi oa Mesifa: Ho hōla ho amana le ho bola ha ho bolaoa' meleng le ho sebetsa ha mesifa. Ho nahanoa ka litoeba ho bontšitse hore tlatsetso ea NMN e ka tsoela pele ho sebetsa, boleng ba mesifa, le mamello ka ho sireletsa mosebetsi oa mitochondrial le ho ntlafatsa mekhoa ea ho hlaphoheloa le ho lokisa mesifa.
Mosebetsi oa Kelello le Neuroprotection: Ho na le bopaki bo ntseng bo tsoela pele bo khothaletsang hore NMN e ka ba le litlamorao tsa neuroprotective le ho matlafatsa ts'ebetso ea kelello ho holisang. Litlhahiso tsa libōpuoa li hlahile hore tlatsetso ea NMN e ka fetisetsa mohopolo pele, ea fokotsa neuroinflammation, le ho netefatsa khahlano le mafu a amanang le botsofali a amanang le botsofali ka ho ntlafatsa mosebetsi oa mitochondrial le ho ntšetsa pele bophelo ba neuronal.
Katoloso ea Bophelo: Athe litlamorao tsa β-Nicotinamide Mononucleotidenmn mabapi le katoloso ea nako ea bophelo bathong, leha ho le joalo, ho na le lintho tse 'maloa tseo batho ba nahanang ka tsona ka mehlala ea libōpuoa, ho na le tšepiso e hlakileng e hlahang. Bakeng sa ketsahalo, ho batlisisa ka litoeba ho hlahile hore tlatsetso ea NMN e ka eketsa nako ea bophelo, ea lieha ho fokotseha ho amanang le lilemo, le ho tsoela pele ka bophelo bo botle ka ho sireletsa mosebetsi oa cellular le ho lekanyetsa liphello tsa khatello ea kelello e amanang le botsofali.
Ho Lekola Maikemisetso a Mosebedisi:
Ho Batla Boitsebiso: U batla ho bokella tlhahisoleseding e felletseng mabapi le NMN, ho kenyelletsa le mekhoa ea eona ea tlhaho, litlamorao tse ka bang teng lits'ebetsong tse amanang le botsofali, le bopaki ba saense bo tšehetsang tšebeliso ea eona.
Ho Utloisisa Botšepehi: U ikemiselitse ho lemoha mehloli e tšepahalang ea tlhahisoleseling le lipatlisiso tse tšepahalang tsa mahlale ho theha pono e nang le tsebo e nepahetseng mabapi le katleho le polokeho ea NMN.
Ho Fuputsa Liphello: U ka 'na ua thahasella ho hlahloba litlamorao tse ka bang teng tsa tlatsetso ea NMN bakeng sa bophelo bo botle ba motho le bophelo bo bolelele, hammoho le litlamorao tse pharalletseng tsa lipatlisiso tsa botsofali le bophelo bo botle ba sechaba.
Likhetho tsa ho lekanya: Sepheo sa hau se ka kenyelletsa ho hlahloba NMN e le mokhoa oa ho kenella bakeng sa ho khothalletsa botsofali bo botle le bophelo bo bolelele, ho nahanoa ka lintlha tse kang ho sebetsa hantle, polokeho le ho khoneha.
Ho Debunking Maikutlo a Fosahetseng:
Har'a boitsebiso bo bongata bo fumanehang marang-rang, ho na le kotsi ea ho kopana le boitsebiso bo fosahetseng kapa lipolelo tse fetelelitsoeng mabapi le thepa ea NMN e thibelang botsofali. Ka ho hlahlobisisa bopaki bo tebileng le ho khetholla lipakeng tsa lintlha tsa mahlale le lipolelo tse inahaneloang, sengoloa sena se ikemiselitse ho felisa maikutlo a fosahetseng le ho fa babali kutloisiso e fokolang ea bokhoni ba NMN.
Liphello tse sebetsang:
Leha lipatlisiso tsa mahlale mabapi le karolo ea NMN botsofaling le ho phela nako e telele li ntse li tsoela pele ho fetoha, ho bohlokoa ho nahana ka litlamorao tse sebetsang tsa ho kenyelletsa tlatsetso ea NMN bophelong ba motho. Ho tloha menahanong ea litekanyetso ho isa litla-morao tse ka bang teng, ho tsamaisa mathata a β-Nicotinamide Mononucleotidenmn e hloka temoho e hlokolosi le therisano le litsebi tsa tlhokomelo ea bophelo.
fihlela qeto ena:
Qetellong, tabatabelo ea ho manolla liphiri tsa botsofali le bophelo bo bolelele e ntse e le leeto le tsoelang pele le hlohlelletsoang ke bohelehele le boqapi ba mahlale. Leha ho le joalo β-Nicotinamide Mononucleotidenmn e na le ts'episo e le sesebelisoa se ka bang teng morerong ona, katleho ea eona ea 'nete le boemo ba ts'ireletso li hloka hore ho hlahlojoe le ho netefatsoa ka lipatlisiso tse matla tsa mahlale. Ka ho lula u le tsebo le ho hlahloba bopaki ka ho teba, batho ka bomong ba ka tsamaisa sebaka sa mehato e khahlanong le botsofali ka mokhoa o hlakileng le ka temoho.Haeba u batla ho reka sehlahisoa sena, ka kopo ikopanye le rona ho kiyo@xarbkj.com.
References:
https://www.nature.com/articles/s41514-021-00070-7
https://www.cell.com/cell/fulltext/S0092-8674(18)30151-6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293469/
https://www.healthline.com/nutrition/nmn-supplements#what-it-is
